Linear 1 3-diarylpropanoids
Medchemexpress LLC 2'-Hydroxychalcone | 1214-47-7 | 97.45% | 224.25 | 1 ML
2'-Hydroxychalcone | 1214-47-7 | 97.45% | 224.25 | 1 ML
Medchemexpress LLC Naringenin chalcone | 73692-50-9 | 1 MG
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis.
Medchemexpress LLC Naringenin trimethyl ether | 38302-15-7 | 1 MG
Naringenin trimethyl ether is a constituent of twigs and leaves of Aglaia duperreana. It is known for its significant molluscicidal activity, demonstrating an LC50 of 3.9 μg/mL for P. canaliculata. This compound is intended for research use only.
- Constituent of twigs and leaves of Aglaia duperreana
- Exhibits significant molluscicidal activity
- LC50 of 3.9 μg/mL for P. canaliculata
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 25 G
4'-Methoxychalcone regulates adipocyte differentiation by activating PPARγ. It also modulates the expression and secretion of various adipokines in adipose tissue, which are involved in insulin sensitivity. The compound has shown antiproliferative activity against several human cancer cell lines, including A2780, CAL-51, HCT-116, and HT-29, and cytotoxicity against DLD-1 and FHC cells.
- Regulates adipocyte differentiation through PPARγ activation.
- Modulates adipokine expression and secretion in adipose tissue, impacting insulin sensitivity.
- Exhibits antiproliferative activity against human cancer cell lines.
- Cytotoxic to certain human cell lines.
- Originates from plants, specifically Piper nigrum Linn.
Medchemexpress LLC Naringenin chalcone | 73692-50-9 | 50 MG
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. It induces apoptosis, inhibits the production of MCP-1 and NO, and exhibits anticancer activity against glioblastoma. It also possesses anti-inflammatory and anti-allergic properties.
- Induces apoptosis
- Inhibits the production of MCP-1 and NO
- Exhibits anticancer activity against glioblastoma
- Has anti-inflammatory and anti-allergic properties
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 25 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent that exhibits antioxidant and anti-inflammatory properties. It can enhance adipocyte functions and inhibits the release of histamine from rat peritoneal mast cells.
- Anti-allergic agent: orally active and inhibits histamine release from rat peritoneal mast cells.
- Antioxidant activity: possesses antioxidant properties.
- Anti-inflammatory activity: demonstrates anti-inflammatory effects.
- Adipocyte function improvement: can improve the functions of adipocytes.
- PPARγ stimulation: stimulates the activity of PPARγ in NIH-3T3 cells.
- Inhibition of inflammatory mediators: inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages.
- Suppresses allergic asthma: inhibits the type-2 function of CD4 T cells in allergic airway inflammatory mice.
Medchemexpress LLC PI3K/AKT-IN-1 | 3033069-84-7 | 99.64% | C23H23N5O4S | 1 ML
PI3K/AKT-IN-1 is an effective PI3K/AKT dual inhibitor with IC50 values of 6.99 μM for PI3Kγ, 4.01 μM for PI3Kδ, and 3.36 μM for AKT. It exhibits anticancer activity by inhibiting the PI3K/AKT axis and inducing caspase 3 dependent apoptosis.
- Effective dual inhibitor of PI3K/AKT
- Exhibits anticancer activity
- Inhibits PI3K/AKT axis
- Induces caspase 3 dependent apoptosis
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 100 G
This product, 4'-Methoxychalcone, regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity.
- Regulates adipocyte differentiation
- Activates PPARγ
- Modulates adipokine expression related to insulin sensitivity
- Stable under recommended storage conditions
- White to light yellow solid appearance
- High purity of 99.8%
Medchemexpress LLC 4-hydroxychalcone | 20426-12-4 | MFCD00016488 | 99.3% | 224.25 g/mol | C15H12O2 | 1 ML
4-Hydroxychalcone is a chalcone metabolite supplied as a 10 mM solution in DMSO for research use. It is reported to inhibit TNF-α-induced NF-κB activation and to exhibit anti-angiogenic and anti-inflammatory effects, providing a high-purity, ready-to-use stock for cell-based and biochemical assays. Handle under recommended storage conditions and protect from light.
- 10 mM solution in DMSO.
- High purity: 99.3%.
- Molecular formula C15H12O2; molecular weight 224.25 g/mol.
- CAS number 20426-12-4.
- Inhibits TNF-α-induced NF-κB pathway; anti-angiogenic and anti-inflammatory activity.
- Store protected from light; in solvent: -80°C up to 6 months, -20°C up to 1 month.